Lately, Association of Human Whole Blood NAD⁺ Contents With Aging published by a Chinese scientific research team in the authoritative journal Frontiers in Endocrinology caused a sensation in the academic community.

Aimed to investigate the association between human whole blood NAD⁺ contents and aging in a relative large-scale community-based population and further to address the gender impact on this association, the research sets a precedent in the world. It suggests that association of whole blood NAD⁺ contents with aging significantly differed in males and females; the loss of blood NAD⁺ with aging only was observed in males, especially in the middle-aged male population.

The research is jointly directed by Shanghai General Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University (SJTU), Jinan University and BYHEALTH Nutrition and Health Research Institute, in collaboration with many other famous national and international institutions of higher education and scientific research institutes. Filling the gap in studies on the association between human whole blood NAD⁺ contents and aging in a relative large-scale community-based population - gender difference, relevant research findings provide new ideas for steering NAD⁺ related studies.

As an important coenzyme for redox reactions and biochemical metabolism, NAD⁺ is crucial for human health and senility. Age-associated blood NAD⁺ contents decline in human has been evidenced in many scientific studies, most of which are confined to single types of tissues or cells with a disregard for gender difference of subjects.

Under the leadership of Zhou Yong, Researcher of Clinical Research Institute, Shanghai General Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University (SJTU), Ju Zhenyu, Researcher of Jinan University, and Zhang Xuguang, Professor and Executive President of BYHEALTH Nutrition and Health Research Institute, the research team recruited 1,518 Chinese participants aged from 18 to 60 years old from 2019 to 2020 for determining the association between NAD⁺ contents and aging and gender. Researchers said, the association of whole blood NAD⁺ contents with aging significantly differs in males and females. The blood NAD⁺ decreased gradually with aging in men, especially in the middle-aged male population, while the female blood NAD⁺ showed a trend of fluctuations, which might be influenced by sex hormone in speculation.

As the world’s first large-scale study of the association of whole blood NAD⁺ contents with age and gender difference, the research plugs the loophole in gender-related NAD⁺ studies on large population. Relative to reports sourced from foreign literature, all subjects in this NAD⁺ test are Chinese citizens. Thus, its research findings provide insightful and valuable ideas for the Chinese population. It should be noted that the research entails an observation on the association between the level of whole blood NAD⁺ and anemia among female participants. It’s found that NAD+ contents are significantly entwined with morbidity of anemia, i.e., the higher the level of whole blood NAD⁺ is, the less likely women will suffer from anemia. The stunning discovery has been included in the Journal of Cellular and Molecular Medicine, an influential scientific magazine.

Apart from NAD⁺ related studies, BYHEALTH stumbled across PCC1 (procyanidin C1) from specific grape pip extract through cooperation with many specialized institutions in last December. PCC1 can deplete senescent cells with efficiency and safety, thus hailed as a “new breakthrough in the fight against senility”. In the future, the substance is expected to delay, alleviate or prevent age-related pathologies. Yielding fruitful results in the research, BYHEALTH is one step further towards its ambition - securing sustainability of health and youth of the nation.

“Concurrent with PCC1 anti-aging substance discovery, NAD+ related group observation, and relevant mechanistic investigation are an aging-related observational epidemiologic study, aging-related study of association between phenotypes of health and risks of diseases, study on screening of nutritional intervention substances and relevant effects from perspective of anti-aging mechanism, among others, which encompass a wide range of major mechanisms concerned,” said Professor Zhang Xuguang, “Carrying out the preceding studies, the BYHEALTH Nutrition and Health Research Institute is intended to make comprehensive anti-aging evalsuation under multiple mechanisms and biomarkers and attain multi-dimensional and personalized nutritional intervention.”

Source:https://www.frontiersin.org/articles/10.3389/fendo.2022.829658/full

https://onlinelibrary.wiley.com/doi/10.1111/jcmm.17281

Note: World’s first study of association of NAD⁺ contents with aging - data as of March 31, 2022, from five authoritative academic literature search platforms (CNKI, Wanfang, PubMed, Web of Science, and Elsevier ScienceDirect).